Rounding out the top five on the list of 100 women are Raquel Welch, Marilyn Monroe, Britney Spear and Madonna.
Though Aniston, 42, embraced her role as a flirtatious (to put it mildly) dentist in this year's Horrible Bosses, she told the magazine she doesn't always play a siren on screen.
"The least sexy character [I've played] was Jeannie Bueller on the TV version of Ferris Bueller's Day Off," she said.
And as for her own pick for the sexiest woman of all time? There's a deadlock.
"It's a tie between Brigitte Bardot and Gloria Steinem," Aniston tells Men's Health. But if I had to choose one, I'd say Gloria because, well, she's the full package. That's sexy."
